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KMID : 1143520230110040091
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Journal of Korean Society of Oral Health Science
2023 Volume.11 No. 4 p.91 ~ p.97
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Effects of Xerostomia on C-Fos Expression in a Chronic Pain Model in Rats
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Kim Yu-Mi
Park Min-Kyoung
Choi Ja-Hyeong
Jo Min-Jung
Lee Min-Kyung
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Abstract
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Objectives: The purpose of this study was to determine whether xerostomia could improve the level of neuropathic pain. To conduct the study, the change in c-fos expression level in the medulla oblongata was confirmed by xerostomia induction using the chronic neuropathic facial pain model.
Methods: mal-positioned dental implant surgery was performed on the extraction site of the mandibular second molar of rats, and 4-diphenylacetoxy-N- methylpiperidine (4-DAMP) (30mg/kg) was injected intraperitoneally after a pain test on the 4th day after surgery. c-fos was counted only in the lamina I and II regions.
Results: A significant increase in c-fos expression was observed when the maxilla was stimulated compared to the mandible in the group induced both neuropathy and xerostomia.
Conclusions: Therefore, it is considered that xerostomia in the facial area is the cause of the expression of chronic pain and the improvement of pain sensation.
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KEYWORD
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c-fos, medulla oblongata, neuropathic pain, rat, xerostomia
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